Preheat the oven to 350°F (175°C). Grease a baking sheet with cooking spray.
Wipe mushrooms with a damp paper towel. Remove and discard mushroom stems. Finely chop caps, setting them aside.
In a large skillet over medium heat, warm vegetable oil. Cook chopped mushroom caps and garlic until moisture disappears, about 3-5 minutes. Transfer mixture to a bowl to cool for around 10 minutes.
Mix cream cheese, Parmesan cheese, black pepper, onion powder, and cayenne pepper into the cooled mushroom mixture until thick and well combined. Spoon this filling into each mushroom cap, stuffing generously. Arrange stuffed mushrooms onto the prepared baking sheet.
Bake in the preheated oven until hot and liquid forms beneath each cap, approximately 20 minutes.
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